Cat. No.
MABL-583
Application
PET imaging, ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
D2111
From
Recombinant Antibody
Specificity
This antibody recognizes the human cadherin 17. Cadherins are calcium-dependent cell adhesion proteins. It is localized on the surfaces of epithelial cells in regions of cell-cell contact known as adherens junctions. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Alternative Names
Cadherin-17; CDH17; Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin; LI-cadherin
UniProt
Q12864
Immunogen
The original antibody was generated by immunizing GP64 transgenic mice with human cadherin 17.
Application Notes
The binding characterization and epitope mapping of this antibody was done using ELISA. This antibody was capable of binding Huh6 cell line (liver cancer) and AGS cells (gastric cancer) in flow cytometry. Cu64 labelled version of this antibody was also used in the PET imaging of AGS transplant mice (JP2017024991).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
