Cat. No.
MABL-1049
Application
FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
YTH 53.1
From
Recombinant Antibody
Specificity
Recognises CD59 18-20kD cell surface GPI linked glycoprotein broadly expressed by human leucocytes and erythrocytes. This protein is regulator of complement-mediated cell lysis by inhibiting the complement membrane attack complex formation of C8 and/or C9.
Alternative Names
MAC-IP; CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; MAC-inhibitory protein; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; YTH53; YTH-53
UniProt
P13987
Immunogen
T lymphocytes in human PBMC.
Application Notes
Antibody First Published
Davies A, Simmons DL, Hale G, Harrison RA, Tighe H, Lachmann PJ, Waldmann H. CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J Exp Med. 1989 Sep 1;170(3):637-54.PMID:2475570
Note on publication
Describes the preparation of antibody and characterisation of the specificities by immunofluorescence and flow cytometry and complement-mediated cell lysis assays.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
