Cat. No.
MABL-1330
Application
WB, ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
A4
From
Recombinant Antibody
Specificity
This antibody is specific for human cytokeratin 17. Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 17 regulates the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1).
Alternative Names
CK17; CK-17; KRT17; K17; Keratin; type I cytoskeletal 17; Cytokeratin-17; Keratin-17
UniProt
Q04695
Immunogen
The original antibody was generated by panning a semisynthetic phage display library against human epidermal keratin extracted from psoriatic scales.
Application Notes
The binding of this antibody to human cytokeratin 17 was checked using ELISA. This antibody can be used for the identification of human cytokeratin 17 by immunohistochemistry and western blotting (PMID： 15340746).
Antibody First Published
Wang et al. Cloning and characterization of antikeratin human antibodies using a semisynthetic phage antibody library. Arch Dermatol Res. 2004 Nov;296(6)：270-7. PMID：15340746
Note on publication
Describes the generation of an anti-keratin human antibody using phage display technology.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
