Key features and details | |
Cat. No. | MABL-1393 |
Name | Anti-Discoidin Domain Receptor 1 mAbs |
Clone No. | AFD-3E 3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, WB, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds specifically to the extracellular domain of human DDR1. |
Alternative Name | DDR1 |
UniProt | Q08345 |
Immunogen | Recombinant human DDR1 extracellular domain. |
Application Notes | This antibody binds to human Discoidin Domain Receptor 1, a receptor tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates the attachemnt of the cell to the extracellular matrix. This receptor is required for blastocyst implantation during pregnancy, mammary gland differentiation as well as lactation. It promotes smooth muscle cell migration as well as tumour cell invasion. The antibody acts as an antagonist. |
Antibody First Published | Carafoli et al. Structure of the discoidin domain receptor 1 ectracellular egion boudn to an inhibitory Fab fragment recelas features important for signalling. Structure 2012; 20(4):688-697 PMID: 22483115 |
Note on publication | Describes the generation of several antibodies against the discoidin domain receptor and subsequent crystallisation as well as binding studies. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
