| CAT.NO | MBA-0071 |
| NAME | Recombinant Anti-Alpha-Synuclein antibody |
| Isotype and Format | Human IgG1, Kappa |
| Clone Number | NAC32 |
| Alternative Name(s) of Target | SNCA |
| UniProt Accession Number of Target Protein | P37840 |
| Published Application(s) | WB, Block, IHC |
| Published Species Reactivity | Human |
| Immunogen | Biotin-labeled peptide spanning amino acids 53-87 of alpha-synuclein. |
| Specificity | Binds the nonamyloid component of alpha-Synuclein. |
| Application Notes | This is a synthetic IgG binding to alpha-Synuclein which is involved in the regulation of dopamine release and transport. It induces fibrillisation of the tau-protein and reduces the neuronal responsiveness to several apoptotic signals. Involved in the pathogenesis of Parkinson disease. |
| Antibody First Published in | Lynch et al. 2008 An scFv Intrabody against the Nonamyloid component of alpha-Synuclein Reduces Intracellular Aggregation and Toxicity Journal of Molecular Biology 2008; 377:136- 147 PMID:18237741 |
| Note on publication | Describes the generation of an scFv intrabody against the non-amyloid component of alpha-Synulcein and demonstrates its effect in counteracting mutant synuclein aggregation. |
| Size | 200 μg Purified antibody. |
| Purification | Protein A affinity purified |
| Supplied In | PBS with 0.02% Proclin 300 |
| Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
| Concentration | 1 mg/ml. |
