| CAT.NO | MBA-0081 |
| NAME | Recombinant Anti-Insulin-degrading Enzyme antibody |
| Isotype and Format | Mouse IgG1, Kappa |
| Clone Number | Fab-IDE |
| Alternative Name(s) of Target | IDE; Insulin Protease |
| UniProt Accession Number of Target Protein | P14735 |
| Published Application(s) | ELISA |
| Published Species Reactivity | Human |
| Immunogen | Human IDE. |
| Specificity | Binds specificially to human IDE with a Kd of 3.72 nM. |
| Application Notes | This antibody binds human insulin degrading enzyme, which breaks down insulin as well as amyloid peptides and is suggested to play a role in both diabetes and Alzheimer's. Antibody binding does not affect steady-state kinetics of IDE. |
| Antibody First Published in | McCord et al. Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzye. Proceedings of the National Academy of Sciences of the USA 2013; 110(34):13827-13832 PMID:23922390 |
| Note on publication | Describes the generation of an antibody against human IDE and crystallisation of the complex. |
| Size | 200 μg Purified antibody. |
| Purification | Protein A affinity purified |
| Supplied In | PBS with 0.02% Proclin 300 |
| Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
| Concentration | 1 mg/ml. |
