Anti-Urokinase-type plasminogen activator mAbs

Cat. No.

MABL-3175

Name

Anti-Urokinase-type plasminogen activator mAbs

Clone No.

AFD- mAb-112

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, WB

Species Reactivity

Human

Basic Information

Specificity

The antibody binds to pro-uPA with a Kd of   0.8E-9M.

Alternative Name

pro-uPA; urokinase zymogen

UniProt

P00748

Immunogen

Human recombinant single chain pro-uPA.

Application Notes

The antibody binds to and stabilizes   pro-uPA, the zymogen form (inactive) of urokinase-type plasminogen activator.   Active uPA catalyzes the conversion of plasminogen to the active protease   plasmin, a protease that degrades extracellular matrix proteins. T

Antibody First   Published

Blouse et al. 2009 A novel mode of   intervention with serine protease activity:targeting zymogen activation.   Journal of Biological Chemistry 2009; 284(7):4647-4657 PMID:19047064

Note on publication

Describes the generation of a monoclonal   antibody that binds to pro-uPA with subnanomolar affinity.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.