Key features and details | |
Cat. No. | MABL-910 |
Name | Anti-CD38 mAbs |
Clone No. | AFD- MU375 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallography |
Species Reactivity | Human |
Basic Information | |
Specificity | MU375 binds to an epitope close to the C-terminal region of CD38. The residues composing this epitope are: F135, Q139, M142, H205, E239, W241, D252, C254, S274, C275, K276, N277, I278, Y279, R280, K283, F284, C287, V288, P291, E292, S295, C296, T297, S298, I300. |
Alternative Name | Cluster of Differentiation 38; ADP-Ribosyl Cyclase 1; ADPRC1; ADPRC 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide; Glycohydrolase |
UniProt | P28907 |
Immunogen | The C-terminal domain of human CD38 (residue 45–300) was expressed and produced in a yeast expression system. The purified recombinant protein was used as an antigen to immunize llamas. Phage display technology was used to obtain positive clones against CD38. |
Application Notes | The nanobody MU375 has been crystallised with CD38. |
Antibody First Published | Li et al. Immuno-targeting the multifunctional CD38 using nanobody. Sci Rep. 2016 Jun 2;6:27055 PMID:27251573 |
Note on publication | Describes increased CD38 expression in malignant cells and its potential as a drug target for cancer therapy. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
